1865 – Dr. Samuel Mudd, Edward Spangler, Michael O'Laughlen, and Samuel Arnold – all convicted as conspirators in the assassination of President Lincoln – arrived at Fort Jefferson in the Dry Tortugas to serve their prison terms. They joined 552 other prisoners being held there.

1980 – The Key West fishing boats Dos Hermanos and Blanche III arrived in Key West with 48 Cuban refugees, which began the Mariel Boatlift.